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NC Department of Health and Human Services

NCDHHS funds nonprofits, health organizations, and community agencies providing mental health, substance abuse, developmental disability, public health, and social services to vulnerable North Carolinians.

National Institutes of Health

Neuromodulation/Neurostimulation Device Development for Mental Health Applications (R01 Clinical Trial Not Allowed)

National Institutes of Health

Neuromodulation/Neurostimulation Device Development for Mental Health Applications (R21 Clinical Trial Not Allowed)

New Jersey Department of Human Services

NJDHS funds nonprofits and community organizations providing social services including mental health, substance use treatment, disability services, food assistance, and support for vulnerable populations across New Jersey.

Labor

On October 21, 2021, New York State (NYS) Governor Kathy Hochul announced a commitment of $11.1 million in federal workforce development investment to expand the Disability Resource Coordinators (DRCs) network across several Local Workforce Development Areas (LWDAs). This program builds on previous programs like the Disability Employment Initiative (DEI) and Disability Program Navigator, and aims to improve education, training and employment outcomes for individuals with disabilities, including those receiving Social Security benefits, by scaling up services and enhancing support across nearly all LWDAs in NYS.A key partner in the NY SCION effort is the New York Employment Services System (NYESS) under the NYS Office of Mental Health (OMH), which commits $1 million annually to support employment services in participating LWDAs for individuals with disabilities. Through this collaboration, DRCs connect individuals with disabilities to Career Center services, employment referrals, and benefits advisement. NY SCION is currently active in 27 LWDAs, including New York City, covering 48 counties, and has helped more than 11,000 individuals with disabilities access career services to date. The program's ambitious goal is to serve 45,000 individuals with disabilities, significantly improving access to sustainable employment and career pathways.

Department of Health

The purpose of this expanded loan repayment program is to assist the Office of Mental Health, the Office for People With Developmental Disabilities, the Office of Addiction Services and Supports, the Office of Children and Family Services, and the Department of Corrections and Community Supervision to assist with recruitment and retention of registered nurses (RNs) and licensed practical nurses (LPNs) who are employed by those state agencies, or who work in facilities or settings licensed by those agencies and who provide direct care to the underserved populations served by each of the agencies.

Visiting Nurse Service of New York Home Care II

Geriatric Mental Health

Urban Youth Alliance International, Inc.

Court-Involved Youth Mental Health Initiative

Yeshiva University

Mental Health Services for Veterans

Yeshiva University

Mental Health Services for Vulnerable Populations

Young Adult Institute, Inc.

Mental Health Services for Vulnerable Populations

Sunnyside Community Services, Inc.

Geriatric Mental Health

Labor

Funding will be provided to Local Workforce Development Boards (LWDBs) for the up-skilling or re-skilling of workers transitioning from fossil fuel to clean energy positions; the up-skilling or re-skilling of residential workers in weatherization, building performance, and retrofitting, including fees required for industry-recognized credentials; and wraparound services during training, including but not limited to, childcare, transportation, housing, food, mental health services, and substance use treatment or services.

NIMH - National Institute of Mental Health

Project Summary Suicide is currently the second leading cause of death amongst adolescents. Interpersonal dysfunction is a significant risk factor for suicidal thoughts and behaviors (STBs), but it is primarily assessed through self-report methods that are inherently problematic due to subjective retrospective recall bias. By depending on self-report of interpersonal functioning, we overlook crucial information about how at-risk youth are interacting with others. To address these gaps, this K23 proposes mentorship in online social networking (OSN) as an objective, ecologically valid assessment of interpersonal behavior (i.e., texting, engagement on social media) in adolescents with STBs. The research aims of the study are to (1) establish active online interpersonal behavior mechanisms in adolescents with STBs, (2) determine passive online interpersonal behavior mechanisms in adolescents with STBs, and (3) identify mediators (e.g., psychopathology, biological sex) relevant to the relationship between OSN and STBs. Multimodal data (OSN, self/parent/clinician report) will be collected from N=84 13–17-year-olds, with the full range of STBs. One month of active (i.e., texting/posting frequency) and passive (i.e., ratio of time spent on apps to texting, inter-day app/platform switching) OSN data will be collected from adolescents’ smartphones and analyzed using mentored statistical approaches to multimodal data including structural equation modeling (SEM). The candidate proposes training in (1) use of OSN as a real- world assessment of interpersonal functioning behaviors in adolescents, (2) gaining expertise in the relationship between STBs and OSN in adolescents, and (3) gaining skills with relevant multimodal data analysis (e.g., SEM) to understand what psychosocial factors may mediate OSN behavioral mechanisms and suicide risk. A team of multi-disciplinary mentors bring expertise in adolescent developmental psychopathology, computer science, interpersonal functioning, and translational research. Combined with the relevant and diverse resources available at McLean Hospital and Harvard Medical School will ensure this candidate receives the necessary training and support to successfully complete the project and launch the candidate’s career in adolescent suicide prevention. Data will directly inform future R01s leveraging this information to prevent suicide risk in adolescents, including (1) probing diagnostic/assessment specificity, (2) using experimental therapeutics to evaluate change in detected interpersonal behavior mechanisms following established evidence-based treatments for STBs, and (3) the development of mechanism-informed just-in-time adaptive social media/mobile health interventions. Completion of the proposed research and training goals will uniquely position the candidate to become a leader in the highly relevant field of adolescent social media and suicide prevention.

NYS Office of Mental Health

6340 ? Comprehensive PROS with Clinic Personalized Recovery Oriented Services (PROS) is a comprehensive recovery oriented program for individuals with severe and persistent mental illness. The goal of the program is to integrate treatment, support and rehabilitation in a manner that facilitates the individual's recovery. Goals for individuals in the program are to: improve functioning, reduce inpatient utilization, reduce emergency services, reduce contact with the criminal justice system, increase employment, attain higher levels of education and secure preferred housing. There are four "service components" in the program: Community Rehabilitation and Support, Intensive Rehabilitation, Ongoing Rehabilitation and Support and Clinical Treatment. Units of Service: Report the sum of the total monthly units of service for the year 7340 ? Comprehensive PROS without Clinic PROS is a comprehensive recovery oriented program for individuals with severe and persistent mental illness. The goal of the program is to integrate treatment, support and rehabilitation in a manner that facilitates the individual's recovery. Goals for individuals in the program are to: improve functioning, reduce inpatient utilization, reduce emergency services, reduce contact with the criminal justice system, increase employment, attain higher levels of education and secure preferred housing. There are four "service components" in the program: Community Rehabilitation and Support, Intensive Rehabilitation, Ongoing Rehabilitation and Support and Clinical Treatment. This program does not include the optional Clinic Treatment component. Units of Service: Report the sum of the total monthly units of service for the year

National Institutes of Health

Pilot Hybrid Effectiveness-Implementation Trials for Mental Health Interventions (R01 Clinical Trial Required)

NIEHS - National Institute of Environmental Health Sciences

Project Summary The majority of Parkinson’s disease (PD) cases are not caused by an inherited monogenic mutation, and disease etiology involves a combination of genetic and environmental factors. Epidemiological studies show that pesticide exposure, particularly to organochlorine pesticides such as dieldrin, increases the risk of sporadic PD. In a model of increased PD susceptibility, mice exposed to dieldrin during development show male-specific increased susceptibility to adult exposure to the dopaminergic toxicant MPTP and, in data from our previously NIEHS-funded work, α-synuclein (α-syn) preformed fibrils (PFFs). Results in this two-hit model demonstrate that developmental exposure to dieldrin leads to largely sex-specific changes in epigenetic modifications from birth to 9 months of age within pathways related to critical steps in early neurodevelopment, dopaminergic neuron differentiation, synaptogenesis, synaptic plasticity, and glial-neuron interactions, suggesting that developmental dieldrin exposure disrupts critical neurodevelopmental pathways, thereby impacting risk of late-life diseases, including PD. However, the early neurodevelopmental effects of this exposure remain incompletely understood. In addition, while these effects are thought to be mediated by direct impacts of dieldrin on the developing brain as dieldrin crosses the placenta and can be detected in the neonatal brain, disruption of placental serotonin (5HT) has emerged as a potential indirect mechanism of developmental neurotoxicity (DNT). Because the placenta is the primary source of 5HT for the developing fetal brain and proper regulation of placental serotonin is essential for proper fetal neurodevelopment, disruption of placental 5HT can cause behavioral and neurological changes throughout the lifespan. Such disruption by genetic, pharmacologic, or toxicologic mechanisms increases the risk of neurodevelopmental disorders, but long-term outcomes on late-life diseases are largely unexplored. This grant aims to test two related yet independent hypotheses. In Aim 1, we hypothesize that dieldrin, known to disrupt monoaminergic systems in the adult brain, may also affect these systems within the placenta; this disruption of placental 5HT may be an additional indirect mechanism of DNT. In Aim 2, we hypothesize that developmental dieldrin exposure alters the development of fetal and neonatal monoamine systems.

Southwest Area Neighborhood Association

Continuation of a successful household environmental health education center funded by the Environmental Justice Community Impact Research Grant Program in 2006.

Health and Human Services Department

In compliance with the requirement of the Paperwork Reduction Act of 1995 to provide opportunity for public comment on proposed data collection projects, the National Institutes of Health (NIH) will publish periodic summaries of proposed projects to be submitted to the Office of Management and Budget (OMB) for review and approval.

NIDA - National Institute on Drug Abuse

The rapid shift in public perception of psychedelics, coupled with the expansion of their use and policy reform across the United States, has created a unique opportunity to assess the real- world impacts of psychedelic use. Over 7,000 people in Oregon have received legal, supervised psilocybin experiences. Similar services are set to begin in Colorado in 2025, and nine other states are currently considering psychedelic services legislation. Although early phase trials suggest psilocybin may be safe and effective for treating some mental health and substance use disorders (e.g., tobacco use), it is not known whether these effects extend to community- based settings with less standardized screening and counseling support. There is an urgent need to assess the safety of these programs and their impact on substance use, before more voters and policymakers are asked to consider their merits and drawbacks. The Psilocybin Research and Implementation study for Substance use and Mental health (PRISM) study is designed to fill this gap by enrolling a cohort of individuals who use substances and receive Oregon’s state-regulated psilocybin services and comparing them to a group of people who would access these services, if they were available. Using 12 months of rigorous longitudinal surveys and qualitative interviews, PRISM will detect potential safety risks and benefits of regulated psilocybin services and identify specific substances and subpopulations that may be responsive to psilocybin’s effects. The study has three Aims: 1) Assess the impact of state- regulated psilocybin services on safety events in people who use substances, 2) Assess the impact of state-regulated psilocybin services on substance use, and 3) Elicit stakeholder views of the impact of state-regulated psilocybin services on long-term safety and changes in substance use. The PRISM study seeks to generate rigorous real-world evidence that can effectively guide state and federal decision-making. The timing of this work is critical, given the rapid expansion of psychedelic policy reform across the United States. The findings will help shape policies that maximize potential benefits of psilocybin services while minimizing risks, offering a scientifically grounded framework for public health strategies, harm reduction efforts, and future psychedelic regulations.

NYS Office of Mental Health

To provide life and employment skills for OMH inpatients to reintegrate into society

Southwest Area Neighborhood Association

SWAN will conduct surveys of participants in the Healthy Home education programs to study the most effective means of educating builders, medical professionals and the local community in ways that will improve the environmental health of low-income residences in Rochester.

NIMH - National Institute of Mental Health

Project Summary/Abstract As young adults with autism spectrum disorder (YAASD) transition out of the academic supports provided by school, they can experience a degradation of social skills over time. This increases their risk of poor social, academic, vocational, and health outcomes. YAASD require continuous and ongoing skill development in order to maximize their potential; however, there are few services available to YAASD to develop and maintain their skills. While interventions exist in early childhood, mid-childhood, and adolescence, few programs have focused on improving resilience among YAASD. Resilience in ActionTM (RiA): Assessing the behavioral target mechanisms of the RiATM curriculum in young adults with autism, is a proposed research study that will be delivered in both community and academic settings to address the ‘adult world’ needs of YAASD who have exited out of secondary education. RiATM has been pilot-tested with YAASD and found to be highly acceptable (with 100% course completion and high course satisfaction), and contributed to YAASDs’ improved resiliency measured pre/post the course. In the proposed study, we will test the RiA curriculum developed in the San Francisco Bay Area, into 2 new sites (Boston, Massachusetts, and Baltimore, Maryland) – In Aim 1, we will conduct a randomized waitlist control trial with 288 YAASD (between 19-26 years of age) to examine the effectiveness of the RiA curriculum on resiliency targets (e.g. self- determination, self-efficacy, social confidence, emotional regulation). In Aim 2, we will examine whether resilience targets are associated with improvements in mental health and explore the impact on emotional regulation, vocational outcomes, and quality of life over a 12-month follow- up. Aim 3 will focus on studying the implementation of the RiA curriculum across the different sites using an expanded RE-AIM Framework. The proposed study would be the first to test resilience as a mechanism of action of the RiA curriculum for YAASD, and whether resiliency gained contributes to improved mental health and social outcomes in a multi-center trial of community-based partnerships across the US. This study will add to the science of how resiliency interventions can improve YAASD’s mental health, social, educational, and health- related outcomes.

NINDS - National Institute of Neurological Disorders and Stroke

PROJECT SUMMARY Proper cerebellar function is important for many aspects of mental health, as evidenced by the wide range of neurological and neuropsychiatric disorders that have been associated with impaired neural processing in the cerebellum, from ataxia and dystonia to schizophrenia, autism and attention-deficit/hyperactivity disorder (ADHD). To understand how the cerebellum contributes to both motor control and cognitive functions it is necessary to define what kind of inputs it receives, particularly via the massive mossy fiber system, which carries the bulk of all sensory, motor and cognitive signals sent to the cerebellum from the rest of the brain. Furthermore, variations in brain state are likely to alter the information content of mossy fiber inputs and have a major impact on how well and reliably the cerebellum can perform its function. Unfortunately, conventional extracellular recording methods do not offer enough stability and often fail to distinguish signals of mossy fibers from other cell types in the cerebellar cortex. As a result, there is very limited knowledge about mossy fiber activity in cerebellar tasks, and no information at all about state-dependent modulation of mossy fiber responses or which mossy fiber states may be associated with enhanced cerebellar function. The experiments in this application take advantage of Neuropixels probes and a recent semi-supervised deep learning algorithm to overcome previous technical limitations and record for the first time from identified mossy fiber populations while mice perform a cerebellar-dependent eyeblink conditioning task. The analysis of mossy fiber activity, both before and during conditioning trials, is meant to achieve the following goals: (1) to provide new biological insight into the moment-to-moment variability of mossy fiber states, (2) to help define which mossy fiber states are associated with ‘faulty’ vs ‘reliable’ cerebellar function and, (3) to reveal how locomotion and non-invasive stimulation of the prefrontal cortex can be used to steer mossy fibers toward favorable states that are linked to improved performance of cerebellar-driven motor responses. Thus, the findings will have important implications for enhancing cerebellar function, both in health and disease, by developing new therapeutic interventions that can be used to promote beneficial mossy fiber states. Given the well-established role of the cerebellum in the control of movement, it is expected that the findings will impact patients with motor problems most directly. However, cerebellar dysfunction has also been associated with impairments in executive function, abstract reasoning, working memory, high-level language processing and attentional control. To the extent that the neural signature of ‘faulty’ and ‘reliable’ mossy fiber states is similar in regions of the cerebellum involved in these cognitive functions, the aims of this application and the implications for future treatments may apply to them as well.