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National Institutes of Health

Accelerating Solutions to Improve Access and Quality of Empirically-Supported Practices for Youth Mental Health (R01 Clinical Trial Optional)

Seniors Creating Art

Access to Art Expansion- West Seattle is a free weekly art workshops for one-year for the residents living in four Seattle Housing Authority (SHA) Senior Living Buildings in the West Seattle/High Point Neighborhoods. As well as weekly art programming, there will be monthly Intergenerational Creative Nights held at a selected SHA building and a Summer Community-wide ArtWalk taking place in High Point. The purpose of this project is to improve the physical and mental health of participants and provide jobs for artists within the Seattle region.

National Institutes of Health

AIDS Research Center on Mental Health and HIV/AIDS (P30 Clinical Trial Optional)

STATE, DEPARTMENT OF.STATE, DEPARTMENT OF.US EMBASSY BELGRADE

AMERICAN EMBASSY BELGRADE LES SUPPLEMENTAL HEALTH INSURANCE SERVICES

Teatro Dallas (dba)

To support the English-language premiere of Lirica, a play set in South Texas about youth violence in schools, with structured talk-backs on mental health facilitated by a psychologist.

Art Room Denton (dba)

To support Arts for Veterans, a mental health support program for Denton County veterans consisting of structured art classes and open studio sessions.

Substance Abuse and Mental Health Services Adminis

Assisted Outpatient Treatment Program

Department of Labor

AWARD PURPOSE THE PURPOSE OF BOOST GO IS TO PREPARE YOUNG ADULTS FOR EMPLOYMENT THROUGH EDUCATION AND TRAINING, PAID WORK EXPERIENCES, MENTORSHIP, AND LEADERSHIP DEVELOPMENT WITH DELIVERY OF EVIDENCE-BASED PRACTICES INTERVENTIONS. ACTIVITIES PERFORMED BOOST GO WILL SUPPORT JUSTICE INVOLVED YOUNG ADULTS FOR EMPLOYMENT AND VIOLENCE PREVENTION BY 1. HELPING YOUNG ADULTS TO INCREASE THEIR CONFLICT RESOLUTION SKILLS AND DEVELOP STRATEGIES TO PREVENT AND AVOID VIOLENCE. THIS WILL BE ACHIEVED IN PARTNERSHIP WITH SKY RANCH BEHAVIORAL SERVICES TO PROVIDE VIOLENCE PREVENTION, MENTORING, AND LEADERSHIP DEVELOPMENT THROUGH DELIVERY OF EVIDENCE-BASED INTERVENTIONS OF AGGRESSION REPLACEMENT TRAINING® ART) AND MENTORS IN VIOLENCE PREVENTION (MVP) CURRICULUM DESIGNED BY UNIVERSITY OF NORTHERN IOWA CENTER FOR VIOLENCE PREVENTION (CVP). PARTNERS WILL COLLABORATE TO RECRUIT AND TRAIN MULTICULTURAL MENTORS WITH LIVED EXPERIENCE. 2. PREPARING YOUNG ADULTS FOR THE WORLD OF WORK BY HELPING YOUNG ADULTS IDENTIFY CAREER INTERESTS, ATTAIN RELEVANT SKILLS, AND GAIN WORK EXPERIENCE. BOOST GO WILL ENSURE PARTICIPANTS RECEIVE COMPREHENSIVE EMPLOYMENT AND CAREER SERVICES UTILIZING STEP ON UP® CAREER READINESS AND GROWTH FOCUSED CASE MANAGEMENT (GFCM), RESULTING IN A CUSTOMIZED INDIVIDUAL DEVELOPMENT PLAN (IDP). PARTICIPANTS WILL GAIN WORK EXPERIENCE IN EMPLOYMENT, APPRENTICESHIP, INTERNSHIP; AND/OR ON-THE-JOB TRAINING WITH HIGH PRIORITY EMPLOYER PARTNERS HIGH DEMAND CAREERS, BASED ON CURRENT LABOR MARKET INFORMATION (LMI) AND IOWA WORKFORCE DEVELOPMENT TO INCLUDE CHILDCARE, CONSTRUCTION, FOOD/MEAT PROCESSING, HEALTH CARE, MAINTENANCE/ SAFETY, COMMERCIAL TRUCKING, WAREHOUSE LOGISTICS/OPERATIONS, AND WELDING. WRAPAROUND SERVICES TO ADDRESS HOUSING, MENTAL HEALTH, ADDICTION, CHILDCARE, LEGAL SERVICES, WILL BE CUSTOMIZED TO EACH INDIVIDUAL. DELIVERABLES OUTCOMES WILL EXCEED ALL REQUIRED PERFORMANCE OUTCOMES TO INCLUDE A 73% EMPLOYMENT RATE- SECOND QUARTER AFTER EXIT, 65% EMPLOYMENT RATE- FOURTH QUARTER AFTER EXIT, 6,000 MEDIAN EARNINGS, 60% CREDENTIAL ATTAINMENT, 73% MEASURABLE SKILL GAIN, LESS THAN 3% ARRESTS FOR VIOLENT CRIMES, AND LESS THAN AN 8% RECIDIVISM RATE. INTENDED BENEFICIARY BOOST GO WILL REACH AND SERVE 180 YOUNG ADULTS 18-24 YEARS OLD MOST IMPACTED BY POVERTY AND CRIME, WITH PRIORITY ON REACHING MINORITY COMMUNITIES IN THE CENSUS TRACTS. SUBRECIPIENT ACTIVITIES N/A

Department of Labor

AWARD PURPOSE THE PURPOSE OF THE PROGRAM IS TO INTRODUCE AND PREPARE JUSTICE-INVOLVED YOUNG ADULTS FOR THE WORLD OF WORK THROUGH PLACEMENT INTO PAID WORK EXPERIENCES, AND ON A PATH TO MORE EQUITABLE CAREER OPPORTUNITIES WITH THEIR PEERS. ACTIVITIES PERFORMED SERJOBS WILL PROVIDE AN INNOVATIVE, INTEGRATED PROGRAM THAT INCLUDES PREVENTATIVE MEASURES PROVEN TO REDUCE VIOLENT CRIME AND SUPPORT PUBLIC SAFETY AND COMMUNITY WELL-BEING FOR 200 JUSTICE-INVOLVED INDIVIDUALS, DESIGNED BY EVIDENCE-BASED RESEARCH, INFORMED INTERVENTIONS, AND PROMISING PRACTICES THAT INVOLVE COMPREHENSIVE WORKFORCE DEVELOPMENT SERVICES INCLUDING CASE MANAGEMENT, EDUCATION, CAREER EXPLORATION/ PLANNING, MENTORSHIP, OCCUPATIONAL TRAINING LEADING TO INDUSTRY-RECOGNIZED CREDENTIALS, PAID-WORK EXPERIENCE, JOB PLACEMENT, FOLLOW-UP SERVICES, AND TRAUMA-INFORMED CARE THROUGH WARM REFERRALS. SER'S COMPREHENSIVE APPROACH UTILIZES A DIVERSE SUPPORT NETWORK AND MULTIPLE ACCOUNTABILITY LEVELS, ENSURING THAT PARTICIPANTS BECOME PRODUCTIVE, LAW-ABIDING MEMBERS OF SOCIETY; ARE PROVIDED WITH POSITIVE OPPORTUNITIES TO ENGAGE IN PRO-SOCIAL ACTIVITIES, MAINTAIN LONG-TERM EMPLOYMENT; SUSTAIN A STABLE RESIDENCE, AND; SUCCESSFULLY ADDRESS ID ATTAINMENT, LEGAL AND SUBSTANCE ABUSE ISSUES, AND PHYSICAL AND MENTAL HEALTH NEEDS. THROUGH ITS EXPERIENCE, RENOWNED TRAINING AND PRE-APPRENTICESHIP PROGRAMMING, PARTNERSHIPS, AND UNIQUE BLEND OF SERVICES, THE PROGRAM WILL ENSURE THAT PARTICIPANTS ARE PREPARED TO MEET THE NEEDS OF THE LOCAL LABOR MARKETS WITH THE SKILLS VALUED BY EMPLOYERS, RESULTING IN THE ATTAINMENT OF HIGH-GROWTH, HIGH-DEMAND JOBS, SO THEY CAN STABILIZE THEIR LIVES AND BREAK THE CYCLE OF POVERTY AND VIOLENT VICTIMIZATION. DELIVERABLES ENROLLED 200; COMPLETE SOFT SKILLS TRAINING 150; START OCCUPATIONAL TRAINING 150; COMPLETE OCCUPATIONAL TRAINING 140; PARTICIPATING IN PAID WORK EXPERIENCE/OJT 150; EMPLOYMENT ATTAINMENT 135; EMPLOYMENT RATE SECOND QUARTER AFTER EXIT 70%; EMPLOYMENT RATE FOURTH QUARTER AFTER EXIT 60%; MEDIAN EARNINGS SECOND QUARTER AFTER EXIT $5,750; MEASURABLE SKILLS GAIN 70; ARRESTED FOR VIOLENT CRIMES <5%; RECIVIDISM <10% INTENDED BENEFICIARY MALES AND FEMALES IN THE TARGETED GEOGRAPHIC AREA, OR PLAN TO RETURN TO THE AREA UPON CUSTODY RELEASE OR UPON THE CONCLUSION OF OUT-OF-HOME PLACEMENT; AND HAVE BEEN EXPELLED FROM A SCHOOL OR HAD JUVENILE OR ADULT JUSTICE SYSTEM CONTACT, AND HAVE ONE OR MORE RISK-FACTORS ASSOCIATED WITH DELINQUENT OR CRIMINAL ACTIVITY. SUBRECIPIENT ACTIVITIES N/A

Department of Labor

AWARD PURPOSE TO HELP FORMERLY INCARCERATED YOUNG ADULTS GAIN WORK EXPERIENCE TO BECOME PERMANENTLY EMPLOYED IN ORDER TO REDUCE COMMUNITY VIOLENCE AND PREVENT RECIDIVISM. ACTIVITIES PERFORMED OUR PROGRAM IS AN 18-MONTH MODEL WHERE FORMERLY INCARCERATED PARTICIPANTS BEGIN TO HEAL AND WORK ON THEMSELVES. EVERY PROGRAM PARTICIPANT IS ASSIGNED A CASE MANAGER AND A NAVIGATOR TO CREATE A CUSTOMIZED SERVICE PLAN THAT INCLUDES ALL THE WRAPAROUND SERVICES INCLUDING EDUCATION, WORKFORCE DEVELOPMENT, MENTAL HEALTH, TATTOO REMOVAL, LEGAL SERVICES, AND SUBSTANCE ABUSE. ONCE THE TRAINEES/PARTICIPANTS HAVE ACHIEVED SOME OF THE MARKERS ASSOCIATED WITH HEALING IN PHASE 1, THE TRAINEE RECEIVES WORK READINESS TRAINING AND ARE PLACED IN OUR OWN SOCIAL ENTERPRISES TO CONTINUE TO HEAL WITH WRAP AROUND SERVICES AND LEARN THROUGH ON-THE-JOB TRAINING. ONCE THE TRAINEE HAS MET MARKERS IN OUR PHASE 2 WORK-AND-LEARN MODEL, THE TRAINEE WOULD MOVE ON TO ADVANCED TRAINING AND PLACEMENT IN OUR SOCIAL ENTERPRISES FOR FURTHER TRAINING IN OUR PAID WORK EXPERIENCE PROGRAM UNDER OUR CAREER PATHWAYS. IN PHASE 3, THE PARTICIPANTS BECOME A FULL-TIME EMPLOYEE AT HBI OR ARE PLACED WITH OUR EMPLOYER PARTNERS. ALL PARTICIPANTS OF OUR PROGRAM RECEIVE: • MENTORSHIP THROUGH OUR LIVED EXPERIENCED NAVIGATORS ASSIGNED TO EACH PARTICIPANT • INDIVIDUAL DEVELOPMENT PLANS (IDPS) (SERVICE PLAN) • EMPLOYMENT AND CAREER SERVICES; EDUCATION AND OCCUPATIONAL TRAINING; AND TRAUMA-INFORMED, GROWTH FOCUSED CASE MANAGEMENT • WORK READINESS TRAINING • PAID WORK EXPERIENCE IN PHASE 2 OF THE PROGRAM AT MINIMUM WAGE • SUPPORTIVE SERVICES • FOLLOW-UP FOR 12-MONTHS AFTER PROGRAM EXIT DELIVERABLES WIOA PERFORMANCE GOALS: I. EDUCATION AND EMPLOYMENT RATE-SECOND QUARTER AFTER EXIT 70% II. EDUCATION AND EMPLOYMENT RATE- FOURTH QUARTER AFTER EXIT 60% III. MEDIAN EARNINGS-SECOND QUARTER AFTER EXIT $5,750 IV. CREDENTIAL ATTAINMENT 50% V. MEASURABLE SKILL GAINS 70% REO-SPECIFIC INDICATORS OF PERFORMANCE: I. ARRESTS FOR VIOLENT CRIMES THAT ARE COMMITTED AFTER PROGRAM ENTRY. THE GOAL IS LESS THAN 5% II. RECIDIVISM—AS DEFINED AS THE PERCENTAGE OF PARTICIPANTS CONVICTED OF NEW CRIME COMMITTED WITHIN 12 MONTHS OF RELEASE FROM FACILITY, PLACEMENT ON PROBATION, OR DIVERSION WITH A GOAL OF LESS THAN 10% III. ARRESTS, RECIDIVISM, AND RETURNS-TO-INCARCERATION WILL BE BASED ON FOA PARAMETERS INTENDED BENEFICIARY COMMUNITY; FORMERLY INCARCERATED AGES 18-24; EMPLOYERS SUBRECIPIENT ACTIVITIES PEACE OVER VIOLENCE: CONDUCT GROUPS AND ASSIST WITH LEADERSHIP TRAINING SUCCESS STORIES: OFFER CLASSES FOR VICTIMS OF DOMESTIC VIOLENCE PUBLIC WORKS: DEVELOP INSTRUMENTS, REPORTING PROCESS AND EVALUATION CARE4: DEVELOPMENT OF TRACKING SYSTEM

Bureau of Justice Assistance

BJA FY25 Public Safety and Mental Health Initiative

Urban Youth Alliance International, Inc.

Local

Substance Abuse and Mental Health Services Adminis

Children's Mental Health Initiative

Chinese Progressive Association

Study of multiple air pollution sources and impacts in the community, followed by education of community residents about preventing asthma and other respiratory problems.

African American Reach and Teach Health

The African American Reach and Teach, (AARTH), is planning educational activities and forums that focus on chronic diseases and mental health outreach. The forums will take place at 5237 Rainer Avenue South. AARTH will develop and host a series of information awareness activities on chronic diseases including diabetes, chronic kidney disease, and mental illness. Peer leader trainings will also be held. The main goal is to increase awareness and knowledge on how to better address chronic health conditions, reduce the stigma of mental illness and create a network of peer supporters for a healthier, more conscious society. The outreach will take place between January and December 2020.

NIA - National Institute on Aging

ABSTRACT As over 25 million people living with HIV (PWH) in sub-Saharan Africa (sSA) reach older age, determining their risk for mild cognitive impairment (MCI) and Alzheimer’s disease and related dementias (ADRDs) is emerging as a major public health priority. Although neuropsychological testing data exist, it has been limited to young populations and lacked specialist evaluations, brain imaging and biomarkers to determine disease phenotypes and underlying etiologies. Moreover, social and clinical health determinants differ meaningfully in sSA, so risk factors for MCI/ADRDs and their impact on households cannot be extrapolated from other populations. This proposal is led by experts in the epidemiology of HIV in sSA, diagnosis and deep phenotyping of MCI/ADRDs with fluid and imaging biomarkers, and machine learning (ML) methods to elucidate mechanisms. Preliminary data generated by our team include neuropsychological screening of 300 older virologic suppressed PWH in Uganda (mean age >60), and 300 demographically similar people without HIV, showing that >30% of PWH have characteristics of MCI and that brain MRI and ML techniques add critical phenotyping data to standard batteries. Four specific aims are proposed: Aim 1: Determine the prevalence and classification of MCI/ADRDs (1A) and compare trajectories of cognitive performance (1B) between older PWH in Uganda and demographically similar people without HIV. Comprehensive neuropsychological assessments will be completed in older adults with and without HIV in the cohort (n=600) annually during years 1-4. MCI/ADRDs will be identified using multi-disciplinary case consensus criteria to provide diagnoses and underlying etiologies. Aim 2: Identify pathophysiologic contributors to MCI/ADRDs in older adults in Uganda through deep phenotyping with novel plasma biomarkers and neuroimaging. Assessments will include Aβ42/Aβ40, p-tau217, GFAP, and NfL biomarkers and brain MRIs to characterize phenotypes. Aim 3: Estimate the psychosocial and economic impacts of MCI/ADRDs on adult household members in Uganda. We will conduct in-depth interviews (n~40, Aim 3A) to learn about lived experiences of caregivers, and quantitative surveys (Aim 3B) to all adult household members of the cohort (n~1800) on employment and resource use, caregiving burden, quality of life, stigma, social participation, loneliness, and mental health. We will compare participants by the presence vs absence of MCI/ADRDs in the household. Aim 4: Discover and validate novel, multilevel mechanistic models of MCI/ADRDs among older PWH by employing ML methods with the full array of data collected in Aims 1-3. We will determine which combinations of highly dimensional features reliably classify individuals according to MCI/ADRDs profiles. Completing these aims will advance our understanding of MCI/ADRDs epidemiology and its societal impacts in Uganda. In doing so, it will lay the foundation for diagnostic, intervention, and capacity-building efforts to address NIA research priorities.

Tigrean Community Association in Seattle

The Tigreans in Seattle have been disconnected from their families in Ethiopia for over two years due to the unrest and blockage of the region. There is no telephone, electricity, or Internet. Tigreans here are distressed and getting chronic disease like hypertension and mental health disturbances. This project will provide outreach, support, and health resources for Tigreans in Seattle who have lost contact with friends and relatives in Ethiopia. This project will be completed by December 29, 2023.

Ecumenical Center for Religion and Health

Support for music and art therapy sessions to awaken and nurture the artist in San Antonio children who have mental health disabilities.

National Institutes of Health

Developmental AIDS Research Center on Mental Health and HIV/AIDS (P30 Clinical Trial Optional)

Alliance of People with disAbilities

Augment the instruction and hardware at the Independence Technology & Employment Computer Lab to better serve individuals with mental health and other non-visible disabilities.

National Institutes of Health

Effectiveness Trials to Test Mental Health System Interventions (R61/R33 Clinical Trial Required)

Union Settlement Association, Inc.

Implementation of a modern State of the Art EMR system for their Mental Health program. This system will be shared by all clinic staff, through internet or a proprietyary network, allowing centralized, accessible, secure record- keeping and collaboration

NIEHS - National Institute of Environmental Health Sciences

The ovary is a particularly important reproductive organ because it is essential for the production of oocytes and sex steroid hormones. Unfortunately, exposure to environmental endocrine disrupting chemicals (EDCs) can damage the ovary. EDC-induced ovarian damage leads to female reproductive dysfunction, which cannot be prevented or treated by eliminating EDC exposures. It is extremely important to understand the mechanisms by which EDCs damage the ovary so that we can develop strategies to prevent and/or treat EDC-induced reproductive toxicity. Towards this end, the overall goals of the proposed RIVER program are to: 1) unravel the intricate mechanisms underlying EDC-induced ovarian damage and female reproductive dysfunction, 2) decode the multigenerational effects of EDCs on ovarian function and female reproductive capacity, and 3) bridge the gap to human health by elucidating how EDC exposure is associated with ovarian function and reproductive aging in a prospective cohort of midlife women. To address these urgent clinical and public health needs, we will use single cell RNAseq to identify novel pathways of EDC-induced toxicity at the single cell level in the ovary as well as other female reproductive organs, spatial transcriptomics to map EDC-induced changes in gene activity while preserving spatial context, advanced 3-D ovarian follicle culture techniques to uncover the direct effects of EDCs on the ovary in a controlled environment, pioneering in vitro and in vivo experiments that include environmentally relevant individual EDCs and mixtures of EDCs, state-of-the-art LC-MS techniques to detect the concentrations of EDCs that reach the female reproductive organs and determine the ability of the ovary to detoxify or bioactive EDCs, high resolution LC-MS/MS techniques to conduct quantitative global and targeted proteomics, whole genome methylome analysis or reduced-representation bisulfite sequencing (RRBS) to identify the effects of EDCs on cell-type specific DNA methylation patterns in the ovary, spatial epigenome- transcriptome co-profiling to localize EDC-induced changes in specific cell types in the ovary and determine the interaction between EDC-induced methylation and gene expression changes, CRISPR-Cas 9 technology to correct EDC-induced DNA methylation errors in cells, LC-MS techniques at the forefront of the field to measure selected EDCs and biomarkers of reproductive function and aging in a prospective cohort of midlife women, and leading edge statistical models to assess associations between EDC mixtures and selected biomarkers/outcomes. The applicant is uniquely qualified to successfully lead the RIVER program. The applicant served as PI on 24 NIH-funded awards and her research produced over 325 peer-reviewed publications. The applicant has demonstrated a broad vision, conducted ground-breaking research, and made seminal contributions to the understanding of the impacts of EDCs on the ovary and female reproduction. The flexible and sustained RIVER support will help the applicant to continue pioneering and impactful research, mentoring, and leadership in environmental health sciences.

NIA - National Institute on Aging

PROJECT SUMMARY/ABSTRACT Growing evidence suggests that exposure to environmental toxicants contributes to Alzheimer’s disease and related dementias (AD/ADRD). Understanding how environmental exposures contribute to disease onset and progression enables policy and/or pharmacological interventions that prevent, mitigate, or potentially even reverse the deleterious consequences of exposure to environmental toxins. Most studies to date are limited by the inability to measure early life or cumulative exposure to toxicants, availability of brain and other tissues at scale (especially from diverse subgroups that are more likely to encounter pollution and develop AD/ADRD), and/or knowledge of the molecular processes through which toxicants act. To overcome these limits, we will leverage the established infrastructure of the Pathology, Alzheimer’s and Related Dementias Study (PARDoS), a major AD/ADRD cohort study that examines neuropathologic and clinical AD/ADRD traits, to study 2,500 deceased Brazilians of European and African ancestry that lived in and around São Paulo, Brazil. Our overall goal is to examine the association of both particulate matter (PM) and metal exposure with AD/ADRD clinical and pathologic traits. This project tests the hypothesis that humans accumulate pollutants in multiple tissues over their lifespan that alter genetic pathways in the brain that can lead to AD/ADRD. Aim 1 will measure toxicant levels in the lung, bone, brain (late life exposure), and teeth (early life exposure) and relate these exposures to brain pathology to determine relationships between environmental pollution exposures across the lifespan and AD/ADRD neuropathological traits. Aim 2 will focus on brain regions known to be important in AD/ADRD (olfactory bulb and dorsolateral prefrontal cortex) to characterize pollutant deposits at the subcellular level and assess the impact of these exposures on transcriptome profiles in relation to AD/ADRD pathogenesis. Importantly, the scale of our data collection effort enables integrative analyses across aims and the opportunity to examine differences by sex and race. These analyses, and the composition of the population from which data will be collected, will provide novel insights relevant for understanding health disparities. The project is led by experts in neurology, olfaction, epidemiology, toxicology, genomics, and environmental health and it will, for the first time, use direct, quantitative measures of PM exposure and metals to identify genes and molecular networks that connect toxicants to AD/ADRD pathology. Policy and therapeutic interventions informed by an improved understanding the relationship between environmental exposures and AD/ADRD, including molecular mechanisms, could benefit brain health worldwide.