Grants

Agency for Health Care Research and Quality

AHRQ Understanding and Improving Diagnostic Safety in Ambulatory Care: Incidence and Contributing Factors (R01)

West Seattle Junction Association

On December 9th 2023 from 4-9pm at Junction Plaza park in West Seattle we are having a free community holiday festival allowing everyone to submit their artificial intelligence generated art to be projected onto a 7 story building which will be shown for one week after the festival.

NIA - National Institute on Aging

Summary In this proposed research, we aim to develop AI-driven virtual screening pipelines to screen billion-scale compound libraries and predict blood-brain barrier (BBB) permeability, which are critical steps for identifying drug-like lead compounds against AD/ADRD targets, as the current computational methods do not adequately address these crucial needs. First, we will incorporate small molecule foundation models, Bayesian ensemble learning, and active learning to accelerate the docking-based virtual screening pipeline, enabling efficient virtual screening of billion-scale compound libraries. Second, we will incorporate Affinity Selection Mass Spectrometry (ASMS)-based screening and advanced AI/Computational tools to enable similarity-based virtual screening (SBVS) for AD/ADRD targets when their ligand-bound structures are not known. Finally, we will construct a large- scale ΔGSolv dataset and take advantage of the dataset to develop AI/ML models that predict Kp,uu and Pgp ER, providing a more nuanced understanding of brain penetration for small-molecule brain penetrant drugs.

NIAID - National Institute of Allergy and Infectious Diseases

ABSTRACT The mucus layer of the digestive system plays a key role in innate immunity, protecting intestinal epithelium from commensal bacteria, pathogens, and toxins. Goblet cells (GCs), secretory cells residing in the intestinal epithelium, are essential for mucin secretion to form this protective mucus layer and maintain its integrity. Ulcerative colitis (UC) is strongly correlated with a compromised colonic mucus layer and a decrease in the number and function of GCs, eventually resulting in inflammatory flare-ups. Unfortunately, current UC treatments display only limited eƯicacy and high recurrence rates, and mostly target the inflammatory process, without inducing mucosal regeneration. In this proposal, we aim to leverage the powerful regenerative potential of the patient’s own cells by activating colon-resident intestinal stem cells (ISCs) to diƯerentiate into GCs. We hypothesize this will augment mucus secretion and rebuild the broken mucosal barrier, eventually preventing pathogen invasion and the consequent inflammatory cascade. Accordingly, the first aim of our study will include artificial intelligence (AI)-guided identification of small molecules that boost GC diƯerentiation. We plan to build on our expertise in ISC diƯerentiation, combined with leveraging existing large biological datasets, including multi-omics datasets and chemical libraries to identify compounds that stimulate GC diƯerentiation. Our second aim is evaluation of AI-identified compounds in UC murine colon organoids (colonoids), and in colonoids derived from UC patients’ biopsies for identification of the most potent GC inducers in this clinically relevant in-vitro model. Our third aim will be dedicated to assessing the therapeutic impact of the top GC boosting molecules in an acute UC murine model. Our proposed strategy to harness the innate stemness of colonic ISCs is envisioned to result in renewal of the colonic GC pool, enhancement of GC-induced mucus secretion and restoration of the mucus barrier function and its key role in innate immunity. We believe the potent stem-cell boosting molecules identified in this study may eventually be developed into a novel treatment modality to replenish the mucus layer and significantly ameliorate inflammatory flares and related symptoms in UC patients.

National Institutes of Health

AIDS Research Center on Mental Health and HIV/AIDS (P30 Clinical Trial Optional)

The ARTS Council of the Southern Finger Lakes

AIE Local Capacity Building in Chemung, Schuyler & Steuben Counties

Ontario County Arts Council

AIE Regrant Program

Saratoga Arts Inc

AIE: CREATIVE LEARNING GRANTS

Saratoga Arts Inc

AIE: CREATIVE LEARNING GRANTS **RECONSIDERATION**

New York Works EDF 16-17

AIM Photonics Capital

Upstate Revitalization Initiat Round 1

AIM Photonics Capital URI

Upstate Revitalization Initiat Round 1

AIM Photonics Testing and Packaging Center Capital & Working Capital

Upstate Revitalization Initiat Round 1

AIM Photonics Testing and Packaging Center Capital II & Working Capital II

Sp Approp Strategic Proj Program 17-18

AIM Photonics Testing and Packaging Ctr Capital III & Working Capital III

Oregon Business Development Department

AIMCO

Pick Up Performance Co., Inc.

Ain Gordon - Show-Biz Monologues

Munitions Directorate

Air Delivered Effects

Munitions Directorate

Air Dominance Broad Agency Announcement (BAA)

Air Force Office of Scientific Research

Air Force Defense Research Sciences Conference and Workshop Support

Economic Development Initiatives 16-17

Air Innovations Working Capital

Teledyne Instruments, Inc. dba Teledyne API

Laboratory and Measuring and Observing and Testing Equipment

Finance General

NEW HEADER

Hell's Kitchen Air Quality Partnership

A study of multiple sources that contribute to the high asthma rate in the community, particularly traffic congestion and substandard housing, and community education and advocacy.

Starflower Experiences Inc

This project will enable us to finally find out about the quality of the air in the community of Wyandanch. We�ve long been concerned about it. We will then educate the community about the results and examine actions that can